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03/22/10 - Protein Discovery Launches New Fractionation Kits for the Gelfree™ 8100 System at ABRF Conference
KNOXVILLE, TN (March 22, 2010) - Protein Discovery, a leading developer of innovative sample preparation solutions for protein research, today announced the introduction of a new line of cartridge kits for its popular GelfreeTM 8100 Fractionation System. The new fractionation kits provide research scientists with the ability to perform molecular weight-based fractionation with liquid phase recovery over various target mass ranges. Included in the offering are three new cartridge kits. The Low Mass Cartridge Kit is tailored to provide maximum separation resolution of proteins with a molecular weight less than 60 kDa, which is specifically useful in the area of "top-down" protein analysis using mass spectrometry. The Mid Mass Cartridge Kit provides separation across the mass range 3.5 kDa- 150 kDa, which spans over 95% of the predicted proteome of most biological systems. The High Mass Cartridge Kit is specifically designed for targeted enrichment of intact biotherapeutics, providing resolution in the mass range of 60 kDa - 300 kDa. "These new cartridge kits allow Gelfree 8100 users to target a specific molecular weight range that best suits their application," stated Jeremy Norris, PhD, vice president of research and development for Protein Discovery. "The kits were designed with input from leading protein research scientists in application areas ranging from discovery proteomics to pharmaceutical biotherapeutic characterization." All Gelfree 8100 Cartridge Kits include ready-to-use fractionation cassettes for processing up to eight samples in parallel, as well as pre-formulated sample and running buffers. Using the new line of consumables, research scientists are able to load over 5 times more protein than with a standard 1D gel, while recovering proteins in solution for intact protein characterization, isoform determination, and in-solution digestion. The cartridge kits have an extended shelf life of six months from the date of purchase. For more information on the new GelfreeTM 8100 Cartridge Kits, visit www.proteindiscovery.com or call +1-866-670-9038. About the GelfreeTM 8100 Fractionation System About Protein Discovery
10/21/09 - Protein Discovery and New Objective Announce Strategic Co-Marketing Collaboration in Top Down Proteomics
KNOXVILLE, TN and WOBURN, MA (October 21, 2009) - Protein Discovery, Inc. and New Objective, Inc. today announced that they have entered into a strategic co-marketing and development agreement designed to enable and expand key applications for intact protein analysis using mass spectrometry ("top down" proteomics). The companies intend to co-market their respective product lines focused on "sample to spray," which include Protein Discovery's GELFREE™ 8100 Fractionation System for molecular weight-based fractionation of intact proteins and New Objective's PicoFrit® high performance nanobore chromatography columns and Digital PicoView® nanospray sources. Together, this platform enables the production of the most comprehensive top down data available. The firms intend to co-market their products through industry publications and at selected trade shows, and collaborate on the development of new products that improve the data quality and throughput of intact protein analysis using mass spectrometry. About New Objective, Inc. 05/28/09 - Protein Discovery Inc. to Introduce Programmable Molecular Weight Fractionation System at ASMS 2009 Conference
KNOXVILLE, TN (May 28, 2009) - The GELFREETM 8100 Fractionation System is the first instrument for proteomics that partitions complex protein mixtures into user-selectable, liquid-phase molecular weight fractions. Protein Discovery anticipates that the new system will be utilized broadly by proteomics research laboratories in combination with routine research techniques such as IEF, trypsin digestion, western blotting, and LC/MS. The company will display the new system at the ASMS Conference on Mass Spectrometry, May 31 - June 4, at the Pennsylvania Convention Center in Philadelphia, Pennsylvania. "Very soon, Protein Discovery's Gelfree System will be considered essential equipment for proteomics research, especially by scientists who are taking advantage of the resolving power of mass spectrometry to study intact proteins," said Neil Kelleher PhD, professor of chemistry at the University of Illinois at Urbana-Champaign. "A molecular weight-based fractionation that provides intact proteins in solution and with high recovery opens up new paths to get high-value information about the proteome," he added. Jeremy Norris PhD, vice president of research and development at Protein Discovery, notes that, "All the previous methods of molecular weight based fractionation on gels and columns have been low-capacity, low-recovery, too slow, or too limited to a narrow size range. What's different about the Gelfree 8100 System is that it gives high and reproducible recoveries of any fraction from 3.5 kDa to 150 kDa, and you can load each cartridge with up to 8 milligrams of sample so you can study very low abundance proteins." Protein Discovery at ASMS 2009 Interested parties are invited to contact Protein Discovery for a complete time-and-events listing of the company's activities at the ASMS 2009 conference. About Protein Discovery
02/26/09 - Jeffrey A. Komatz Named Chief Financial Officer of Protein Discovery, Inc.
KNOXVILLE, TN (February 26, 2009) - Protein Discovery, Inc., a privately held life sciences company, today announced that it has hired Jeffrey A. Komatz for the position of chief financial officer. Mr. Komatz will be responsible for ensuring the continued financial health of Protein Discovery. As the CFO, Mr. Komatz will plan and manage the company’s administrative activities, including finance, legal, investor relations, tax, human resources and facilities. Mr. Komatz has substantial and diverse experience directing the administrative functions of medical and life science companies and positioning them for successful sales. Mr. Komatz will report directly to Chuck Witkowski, II, president and chief executive officer of Protein Discovery. "I'm delighted that Jeff has joined Protein Discovery as our chief financial officer,"" said Witkowski. "His expertise in corporate administration, finance and accounting, combined with his experience growing successful life science companies will ensure that we operate efficiently and are well-positioned for growth." Prior to joining Protein Discovery, Mr. Komatz was the vice president and corporate controller at Tutogen Medical, Inc., a public company that was sold to RTI Biologics, Inc. (NASDAQ: RTIX) in February 2008. Previously, he was vice president of finance and controller at Cellomics, Inc., which was sold to Fisher Scientific (NYSE: TMO) in August 2005. Mr. Komatz is a certified public accountant and holds a Bachelor of Science degree in business administration (accounting) from Ohio State University. About Protein Discovery
02/09/09 - Agilent Technologies, Protein Discovery Announce Exclusive Agreement for Worldwide Distribution of PPS Silent® Surfactant
SANTA CLARA, CA, AND KNOXVILLE, TN (February 10, 2009) -Agilent Technologies (NYSE: A) and Protein Discovery, Inc. today announced their distribution agreement for PPS Silent Surfactant, a specialized reagent from Protein Discovery used to prepare biological samples for mass spectrometry analysis. The exclusive agreement encompasses aspects of sales, marketing and support for PPS Silent Surfactant. PPS Silent Surfactant is an acid-cleavable, zwitterionic detergent that helps researchers produce high-quality mass spectra from biological samples. The patented reagent is particularly useful for solubilizing hydrophobic proteins for extraction and preparative digestion. "PPS Silent Surfactant is a powerful addition to Agilent’s sample-preparation product offering and improves the customer experience and capability for LC/MS-based research," said Bill Molnar, Agilent vice president and general manager, Genomics and Bioreagents. "It can be used at any stage of the mass spec sample-preparation process without interfering with separation mechanisms, ESI or detection. It relieves detergent interference problems and improves recovery and identification of more proteins. These advantages enable researchers to produce better data and get even greater satisfaction from the other product elements of our comprehensive mass spectrometry portfolio." "This agreement represents a significant milestone in Protein Discovery’s commercialization of specialty products for preparative proteomics," said Chuck Witkowski, president and chief executive officer of Protein Discovery. "Agilent's status as an innovator in sample preparation, combined with its extensive global distribution network, make Agilent a great partner for Protein Discovery." Effective immediately, Agilent customers can place orders for PPS Silent Surfactant through Agilent’s Life Sciences and Chemical Analysis division at http://www.stratagene.com/products/displayProduct.aspx?pid=880. About Protein Discovery
About Agilent Technologies
09/24/08 - Bioanalytical Separations Pioneer Milos Novotny Joins Protein Discovery's Scientific Advisory Board
KNOXVILLE, TN--(September 24, 2008) - Renowned separations science expert Milos Novotny, PhD, has joined Protein Discovery's scientific advisory board. Protein Discovery will call upon Professor Novotny's deep knowledge of electrophoretic and chromatographic separations as the company continues to develop and commercialize sample preparation systems for mass spectrometry. "Protein Discovery has commercialized electrophoretic sample preparation in a unique and immediately useful way," said Professor Novotny. "The work the company is doing with parallel sample preparation systems is critical to the progress of proteomics," he added. Welcoming Milos Novotny to the scientific advisory board, Protein Discovery president and chief executive officer Chuck Witkowski said, "Professor Novotny's specific experience developing high-resolution, high-sensitivity analytical systems is an incredible resource to our R&D program. Our customers are the ones who will benefit most from his intellectual and practical contributions." Milos Novotny, Ph.D., holds the title of distinguished professor at Indiana University's Department of Chemistry, where he is also the Lilly Chemistry Alumni Chair and an adjunct professor of medicine at the same university. Professor Novotny is the director of the Institute for Pheromone Research and of the National Center for Glycomics and Glycoproteomics. His current research is focused on improving the resolution of complex biological mixtures and mass-spectrometry based methods of glycoprotein analysis. Professor Novotny has received dozens of awards acknowledging his contributions to scientific discovery and teaching. Recently, he has received the Dal Nogare Award for Excellence in Separation Science, and the American Chemical Society Award in Analytical Chemistry. About Protein Discovery
03/28/08 - Protein Discovery, Inc. Completes $10 Million Private Equity Financing — Funds Will Accelerate Market Entry of Mass Spectrometry Sample Preparation Products
KNOXVILLE, TN (March 25, 2008) - Protein Discovery, Inc., a developer and marketer of products that simplify biological sample preparation for mass spectrometry applications, today announced that the company has closed a $10 million Series C round of equity financing. The investment was led by Santé Ventures and was joined by previous investors, including Memphis Biomed Ventures, the Southern Appalachian Fund, and the Nashville Capital Network. Protein Discovery will use the funds to boost market entry activities of its flagship product, the PassportTM 1200 Sample Prep System. "Protein Discovery has developed a unique product that significantly improves the otherwise cumbersome process required to prepare biological samples for mass spectrometry analysis in common life science R&D applications such as protein biomarker discovery and small molecule quantification," said Kevin Lalande, managing director of Santé Ventures. "By simplifying multiple sample preparation steps into a single-step, parallel format disposable cartridge, the product allows customers to generate more reliable data faster, easier, and at a lower cost. The technology addresses a key pain point, which combined with a quality management team, makes Protein Discovery a promising investment for us." Mr. Lalande will join Protein Discovery's Board of Directors. The Passport System is used to prepare clinically relevant biological samples for analysis by mass spectrometry. Up to 96 samples can be prepared for analysis in less than an hour, compared to days using existing techniques. The system is in use at six leading mass spectrometry centers throughout the world and was presented in two invited oral presentations in March 2008 at the Pittsburgh Conference. The first peer-reviewed journal publication outlining the scientific foundation for the technology was published in Analytical Chemistry in March, 2008. "There's still too much 'artistry' involved in conventional methods of sample preparation for mass spectrometry," said Chuck Witkowski, president and chief executive officer of Protein Discovery. "By directing our efforts toward simplifying the process, we aim to allow mass spectrometry to grow steadily into exciting high-volume clinical applications. Kevin and his colleagues at Santé are the perfect partners to help us implement this vision and accelerate commercialization of our innovative products." About Protein Discovery Protein Discovery is a privately held life science company that provides products that simplify and accelerate the preparation of complex biological samples for analysis by mass spectrometry. For additional information, please visit www.proteindiscovery.com. About Santé Ventures Santé Ventures is a specialized venture capital firm founded in 2006 by a group of partners with deep healthcare investment and operations experience. In addition to capital, the firm provides its portfolio executives with additional healthcare domain expertise, an extensive network of relationships and singular industry focus. Santé invests exclusively in early-stage companies developing innovative new medical technologies and healthcare services. For more information, please visit www.santeventures.com.
03/27/08 - Passport® 1200 Sample Prep System Simplifies Preparation of Biological Samples for Large Mass Spectrometry Studies
NORTH BETHESDA, MD (March 17, 2008) - Protein Discovery, Inc., a maker and marketer of products that simplify mass spectrometry sample preparation, today announced a new product that prepares statistically significant numbers of biological samples, quickly and economically, for analysis by mass spectrometry. The Passport 1200 Sample Prep System enables high-throughput mass spectrometry for clinical research by replacing a host of conventional sample preparation methods and protocols with a simplified, automated electrophoretic process. Protein Discovery made the announcement at the fourth annual conference of the United States Human Proteome Organization (US HUPO), currently underway in North Bethesda, Maryland. The Passport 1200 Sample Prep System prepares low molecular weight analytes for mass spectrometry analysis from complex biological mixtures such as serum, CSF, and tissue homogenates. The system prepares 96 samples in one hour, automatically. "Conventional sample preparation methods for mass spectrometry, such as those based on protein precipitation, affinity columns, ion exchange columns, membranes and so on, do not provide the combination of specificity, reproducibility, throughput, and cost to support large-scale biomarker studies," said Chuck Witkowski, chief executive officer of Protein Discovery. "By taking a different approach, we were able to automate sample prep procedures in a 96-well, parallel format, while introducing a number of other advantages, such as the ability to have up to 96 different experiments going on simultaneously." "One of the key performance features of the Passport 1200 System is sample preparation reproducibility," said Protein Discovery's director of mass spectrometry, Jeremy Norris PhD. "It doesn't matter anymore who in the lab is preparing your samples. If you select an automated Passport 1200 System program that enriches a certain population of analytes, that's what will happen every time." Pricing, delivery, and additional technical information on the Passport 1200 Sample Prep System is available from Protein Discovery, Inc. Call (865) 521-7400 or visit www.proteindiscovery.com. Protein Discovery is a privately held life science company that provides products that simplify the preparation of clinical samples and other complex biological mixtures for analysis by mass spectrometry. For additional information, please visit www.proteindiscovery.com.
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ASMS 2010 May
23 - 27, 2010 Booth #49
May 23 - 27, 2010, Salt Lake City, UT
Start Your Day with Protein Power Breakfasts! Improving Shotgun Proteomics by Multiplexed MW Separation of Intact Proteins Increasing Coverage in Bottom-Up Proteomics: Comparing GeLC vs. Gelfree Fractionation Top-Down Proteomics using Gelfree/MS Realizing High Throughput Quantitative Top-Down Proteomics Keep Your Enemies Closer: A Critical Evaluation of SDS Depletion Strategies for Top-Down GELFREE/MS Method Development for Intact Antibody Isolation and Characterization using LC-MS
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