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Scientific Advisory Board
Richard M. Caprioli, Ph.D.
Dr. Caprioli is the Stanley Cohen Professor of Biochemistry and Director of the Mass Spectrometry Research Center at the Vanderbilt University School of Medicine. He is also currently Professor in the Departments of Chemistry and Pharmacology at Vanderbilt University. Dr. Caprioli received his B.S. degree from Columbia University and his PhD degree in 1969 from Columbia University under the guidance of Professor David Rittenberg. Following his PhD studies, Dr. Caprioli completed a one year post-doctoral fellowship at Purdue University with Professor John H. Benyon. Dr. Caprioli is interested in the use of mass spectrometry for the analysis of compounds in biological systems. Current work includes the use of electrospray and laser desorption ionization methods with biological tissues and samples. Applications have focused on the development of this instrumentation and associated methodologies to achieve ultra-high sensitivity detection of endogenous compounds (e.g., neuropeptides) in live animal systems. Recent work involves the development of Imaging Mass Spectrometry, a technique whereby molecular images of peptides, proteins, drugs and other compounds are localized in tissue sections with molecular weight specificity. Dr. Caprioli has been a member of the American Society for Mass Spectrometry since 1975; he is currently Past-President of this society, having recently served two years each as President and Vice President for Programs. He is also a member of the American Society for Biochemistry and Molecular Biology. Dr. Caprioli has been the Editor-in-Chief of the Journal of Mass Spectrometry since 1990. Dr. Caprioli has published over 300 scientific papers, including three books, and is currently co-editing a volume of Encyclopedia of Mass Spectrometry.
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David L. Hachey, Ph.D.
Dr. Hachey is a Professor of Pharmacology and Biochemistry at Vanderbilt University and a member of the Mass Spectrometry Research Center where he directs the Mass Spectrometry Instrument Facility. Dr. Hachey holds a B.A. in Chemistry from Oakland University and a Ph.D. in Chemistry from the University of California, Santa Barbara. Dr. Hachey’s research interests include the pharmacology and physiology of lipid metabolism, analytical proteomics, bioseparations and mass spectrometry. He has published over 130 research papers and book chapters. In 1978 Dr. Hachey received the University of Chicago Award for Distinguished Performance at the Argonne National Laboratory, where he was an Associate Scientist from 1971 to 1980. From 1980 to 1998, Dr. Hachey held the positions of Assistant and Associate Professor of Pediatrics at Baylor College of Medicine in Houston, Texas, prior to moving to Vanderbilt University in 1998. He is a consultant for Advanced Breath Diagnostics, which develops targeted diagnostic tests using stable isotopic tracers and mass spectrometry. Dr. Hachey is a long time member of the American Chemical Society and the American Society for Mass Spectrometry.
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Nathan S. Lewis, Ph.D.
Dr. Lewis is the 2002 George L. Argyros Professor of Chemistry at the California Institute of Technology. Dr. Lewis has also served as the Principal Investigator of the Beckman Institute Molecular Materials Resource Center at Caltech since 1992. Dr. Lewis holds a B.S. in Chemistry from the California Institute of Technology and a Ph.D. in Chemistry (Inorganic) from the Massachusetts Institute of Technology. His research interests include semiconductor electrochemistry and photoelectrochemisry, scanning tunneling microscopy of organic monolayers, and artificial olfactory systems using arrays of chemical sensors. Dr Lewis has been an Alfred P. Sloan Fellow, a Camille and Henry Dreyfus Teacher Scholar, and a Presidential Young Investigator. He received the Fresenius Award in 1990 and the ACS Award in Pure Chemistry in 1991. He has published over 200 papers, supervised approximately 50 graduate students and postdoctoral associates, and has authored over 30 patents. Dr. Lewis is currently a member of JASON, MITRE Corporation, where he serves as an Advisor and Consultant to the administrative branch of the U.S. Government on various issues related to national security. Dr. Lewis also serves as a Consultant and Scientific Advisory Board Member for Orchid Biosciences (Nasdaq: ORCH) and a Technology Advisory Council member of British Petroleum (BP) /ARCO/AMOCO (NYSE: BP).
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Michael J. Sailor, Ph.D.
Dr. Sailor is a Professor of Chemistry and Biochemistry at the University of California, San Diego. Dr. Sailor holds a B.S. in Chemistry from Harvey Mudd College and a Ph.D. in Chemistry from Northwestern University for work on the synthesis of organometallic metal clusters in the laboratory of Professor Duward Shriver. Dr. Sailor subsequently completed postdoctoral research studying semiconductor photoelectrochemistry with Professor Nathan S. Lewis at Stanford and Caltech. Dr. Sailor is a world-recognized expert on nanophase materials and sensor technologies. Specifically, his current research interests focus on the chemistry of nanophase semiconductors, phosphors, and biomaterials, with emphasis on chemical and biological sensors. He has been an Alfred P. Sloan research fellow (1994-1995), a Camille Dreyfus Teacher-Scholar (1994), and has been awarded the Arnold and Mabel Beckman Young Investigator Award (1993), National Science Foundation Young Investigator Award (1993-1998), and the University of California Presidential Award for Excellence in Undergraduate Research (1995). Professor Sailor is a member of the Executive Steering Committee of the UCSD Materials Science division, and he is on the editorial boards of Advanced Materials, Inorganic Chemistry Communications, and Chemtracts-Inorganic Chemistry. He is the author of 5 patents and over 70 research publications, in subjects related to materials chemistry, sensors, and electrochemistry. He has supervised over 60 graduate, undergraduate, and post-doctoral students. Dr. Sailor’s group has recently invented microscale detectors for explosives and nerve warfare agents, which are under development/commercialization by Alpha M.O.S. (Euroclear: 6280), as well as a novel biosensor based on thin films of nanocrystalline silicon, which is being commercialized by TREX Enterprises, a privately held company with approximately 150 employees.
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Mike Story
As a scientist, inventor, and successful business executive, Mike Story adds pertinent technical knowledge and practical business experience to Protein Discovery's advisory resources. A key figure in the development and commercialization of mass spectrometry for biological sciences, Mike Story co-designed the first commercial mass spectrometry system based on quadrupole technology and was a co-founder of Finnigan Corporation. Among his other accomplishments, Mr. Story initiated and successfully brought to market three major new mass spectrometry technologies originating from academic institutions. He has detailed the requirements and specified the development of mass spectrometer-based instrumentation for analytical biochemists and molecular biologists, managed research and engineering groups, and founded, staffed, and managed successful distribution organizations worldwide. Mike Story is the author of numerous technical articles in journals and trade publications, has written two chapters of books on quadrupole mass spectrometry, and holds seven patents in the area of mass spectrometry. He currently serves on the board of directors of Syagen Technology, Inc., and provides technology evaluation and other consulting services to the life science industry. Mr. Story graduated from the University of California at Berkeley with a BS degree in Chemistry.
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Frantisek Svec, PhD
Famous for his contributions to the development of monolithic separations materials, Frantisek Svec, Ph.D. represents a deep resource of materials science expertise that supports and propels MALDIplexTM sample preparation cartridge development. Dr. Svec is a leader in the discovery and development of technologies for controlling polymeric attributes such as pore surface chemistry, porosity, surface area, pore size, and pore size distribution. This technology enables the design and manufacture of monolithic materials that are structurally and chemically optimized for specific applications. Frantisek Svec is author or co-author of hundreds of peer-reviewed scientific papers, and has written or edited numerous book chapters related to his fields of expertise. He is president of the California Separations Science Society and serves on the editorial boards of several prestigious scientific journals. In 2005, he won the M.J.E. Golay Award and the EAS Award for his contributions to the field of separations science. Dr. Svec received a B.S. degree in chemistry and a Ph.D. degree in polymer chemistry from the Institute of Chemical Technology, Prague (Czech Republic). Dr. Svec presently conducts research at the University of California, Berkeley, and the Lawrence Berkeley National Laboratory.
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Dr. Thomas Thundat
Dr. Thundat is a Distinguished Research Scientist and leader of the Nanoscale Science and Devices Group at the Oak Ridge National Laboratory. He is also an Adjunct Professor of Physics at the University of Tennessee and a Visiting Professor at the University of Burgundy, France. Dr. Thundat holds a M.Sc. in Physics from the Indian Institute of Technology and a Ph.D. in Surface Physics from the State University of New York at Albany. Dr. Thundat’s research interests focus on novel physical, chemical, and biological detection using micro and nanoscale technologies. His expertise includes physics and chemistry of interfaces, solid-liquid interface, biophysics, scanning probes, and quantum confined atoms. Dr. Thundat has over 160 publications and six book chapters in surface and interface science, characterization of biomolecules, and chemical, physical, and biological sensor development. Dr. Thundat is a prolific inventor, as he holds 17 issued patents issued and seven patents pending for his work on this and related technologies. Dr. Thundat is the recipient of numerous awards that include the USDOE Young Scientist Award, R&D 100 Award, Inventors Hall of Fame Award, AMSE Emerging Technology Award, and several awards for invention, publication, and research and development at the Oak Ridge National Laboratory. Dr. Thundat is a co-inventor of key technology that is exclusively licensed to Protein Discovery, Inc.
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John Yates III, Ph.D.
Dr. John Yates is well known for his role in making mass spectrometry the central analysis method of proteomics research. Dr. Yates is a professor of cell biology and the principal investigator of the Scripps Research Institute's highly productive Proteomic Mass Spectrometry Laboratory, a hotbed of invention and a demanding proving ground for new proteomics technologies. In pursuit of answers to biological questions about cancer, heart disease, infectious disease, and many other research areas, Dr. Yates has developed key scientific investigation methods such as tandem mass spectrometry for peptide sequencing, the multi-dimensional protein identification technique (MudPIT), "shotgun" proteomics, and SEQUEST, a powerful and essential computer program for analyzing protein mass spectra. He is the author or co-author of hundreds of proteomics research articles and has received numerous awards recognizing his contributions to the field, including the Biemann Medal, The American Society for Mass Spectrometry Research Award, and the Per Edman Award. Dr. Yates is an Associate Editor of the scientific journal Analytical Chemistry, and serves on the Board of Reviewing Editors of the journal Science. Dr. Yates earned BA and MS degrees from the University of Maine, and the PhD degree in Chemistry from the University of Virginia.
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